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It is the latest financial company to indicate how it is repositioning to cope with the UK's exit from the EU.
Barclays said Ireland provided a "natural base" for the bank as it has operated there for 40 years already.
"In the absence of certainty around... an agreement, we intend to take necessary steps to preserve ongoing market access for our customers."
Financial firms have been drawing up contingency plans for how they will continue to access the European single market when the UK leaves the trading bloc.
Companies in other sectors have also been making plans. Earlier on Friday, UK airline EasyJet said it was planning to set up a subsidiary in Austria.
The airline must have an air operator certificate in an EU member country to allow it to continue flying between member states after Brexit.
Barclays currently employs about 100 staff in Dublin and the bank said it was talking to regulators over extending its licence there.
Ireland's Government Enterprise and Innovation Minister Frances Fitzgerald said Barclays decision to expand its presence in Dublin was "a strong vote of confidence in Ireland's growing importance as a gateway into the single market".
Dublin appears to be well-placed in the race to pick up business from financial firms as they plan their post-Brexit strategies.
Insurer Legal & General said in May that it planned to locate parts of its business to the Irish capital. Standard Life is also thought to be likely to choose Dublin.
US bank JP Morgan is buying a Dublin office with space for 1,000 staff and its chief executive has also held a meeting with the Irish prime minister.