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Having changed policy to avoid a possible rebellion on abortion in Northern Ireland, ministers should have enough support due to their agreement with the Democratic Unionist Party.
Labour is attempting to amend the speech to incorporate its manifesto pledges.
And some MPs will try to change it to keep the UK in the EU single market.
But the government is likely to see these off when it comes to the vote.
With support from the DUP's 10 MPs, the government has a working majority of 13.
Earlier the government announced women from Northern Ireland would get free access to abortions on the NHS in England, as it came under pressure from MPs.
Women from Northern Ireland currently have to pay to have an abortion in England, and the government faced a possible Commons defeat with MPs from the major parties backing an amendment calling for action.
Labour's amendment calls for Brexit to deliver the "exact same benefits" as the EU single market and customs union, as well as scrapping tuition fees, increasing public spending and ending the public sector pay cap.
Shadow chancellor John McDonnell described the Queen's Speech as a "threadbare scrap of a document" with many of the Tories' key pledges removed since the general election.
He also claimed the cabinet was divided over Brexit, with "weekly changes of direction".
Chancellor Philip Hammond challenged him to a "grown-up" debate about public spending, accusing Labour of asking voters "would they like someone else to pay higher taxes?"
Opposition divisions over Brexit could be revealed by the other amendment, from Labour's Chuka Umunna, which would aim to keep the UK in the customs union and single market - not the position advocated by Labour's front bench.
During the debate, one Tory MP, Heidi Allen, criticised the arrangement between her party and the DUP, saying she could "barely put into words" her "anger" at the £1bn deal.
Ms Allen, who also criticised the Tories' general election campaign, said she wanted to put on record her "distaste for the use of public funds to garner political control" and warned that "never again" should a government prioritise spending in such a way.